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  • National Institutes of Health, Schizophrenia Research Program

    Agency: National Institutes of Health

    OVERVIEW: Offers outpatient and inpatient study and treatment.

    SERVICES:
    1) OUTPATIENT STUDY: NIMH GENETIC OF SCHIZOPHRENIA,

    ELIGIBILITY REQUIREMENTS:
    Adults between the ages of 18 and 55 must carry a diagnosis of schizophrenia or schizoaffective disorder, depressed type and be free of extensive substance abuse, neurological, or medical problems. Full biological siblings, between the ages of 18 and 55, who are free of extensive substance abuse and health problems are also invited to participate. Parents are invited to donate a sample of blood if possible.

    TREATMENT/ PROCEDURES:
    Participation can be limited to a blood draw for genetic analysis and a confidential clinical interview. Qualifying adults can also participate in one or more of the following procedures: Neuroimaging (MRI & fMRI), Magnetoencephalography (MEG testing), Neuropsychological Testing and Neurological exams. Parents will be asked to contribute blood samples and share information about their child's birth and development. Travel and lodging expenses are paid when possible and all family members are compensated.

    2) SCHIZOPHRENIA, COGNITIVE ENHANCEMENT STUDY

    ELIGIBILITY REQUIREMENTS:
    Adults between the ages of 18 years & older either normal volunteers or must carry a diagnosis of schizophrenia or schizoaffective disorder, depressed type and be free of extensive substance abuse neurological or medical problems.

    TREATMENT/PROCEDURES:
    A three week research period includes a blood draw, neuroimaging and neuropsychological testing. All candidates will be previously assessed for eligibility with blood tests, an EKG, a physical exam and structured interviews. Medications used for the trial includes Tolcapone and Modafinil, two FDA approved drugs used for the treatment of Parkinson's Disease and day time sleepiness, respectively. Patients with schizophrenia will be admitted for the study to the inpatient unit for a period of 6-12 weeks while normal volunteers will participate in the study on an outpatient or inpatient basis.

    3) SCHIZOPHRENIA INPATIENT EVALUATION STUDY

    ELIGIBILITY REQUIREMENTS:
    Adults 18 to 50 years old with a likely diagnosis of schizophrenia or schizoaffective disorders, free of serious medical or neurological disorders, and free of extensive substance abuse or significant risk of violence to self or others. Patients should be competent to give voluntary and informed consent.

    TREATMENT/PROCEDURES:
    Six-month inpatient study includes evaluations both on and off of medications and involves neuroimaging (MRI, PET, fMRI, magnetoencephalography (MEG), neuropsychological tests, eye tracking, and neurological exams. During their stay, patients are expected to be involved in a clinical program that includes patient education groups, occupational, recreational, music and art therapies.


    • Main:
      • 301-435-8970
    • Fax:
      • 301-402-5503
    • Toll-Free:
      • 888-674-6464
    • Main:
        schizophrenia@intra.nimh.nih.gov
    • Main Contact:
      • name: Helene Dobov
    • Senior Worker:
      • name: Dr. Jose Apud

    Location(s):

    • Clinical Brain Disorders Branch
      Clinical Brain Disorders Branch
      Bethesda, MD 20892-1377

    Agency: National Institutes of Health

    Languages Available:

    Payment Description: None.

    Intake and Eligibility: Specific eligibility.

    Areas Served:
    • County



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